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Rabbit Anti-Syndecan-1/BF555 Conjugated antibody (bs-1309R-BF555)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1309R-BF555
英文名稱1 Rabbit Anti-Syndecan-1/BF555 Conjugated antibody
中文名稱 BF555標(biāo)記的多配體蛋白聚糖1抗體
別    名 SDC1; SDC; SYND1; Syndecan I; SyndecanI; Syndecan-I; syndecan; Sdc1; Syndecan1; AA408134; AA409076; Sstn; syn-1; CD138; CD 138; CD-138; CD138 antigen; Heparan sulfate proteoglycan fibroblast growth factor receptor; SDC 1; Syndecan1 precursor; SDC1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  神經(jīng)生物學(xué)  細胞膜受體  細胞粘附分子  細胞表面分子  糖蛋白  上皮細胞  內(nèi)皮細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat, Cow,  (predicted: Mouse, Chicken, Dog, Pig, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD138
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008].

Function:
Cell surface proteoglycan that bears both heparin sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.

Subunit:
Interacts with CDCP1.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form.

Post-translational modifications:
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.

Similarity:
Belongs to the syndecan proteoglycan family.

Database links:

Entrez Gene: 6382 Human

Entrez Gene: 20969 Mouse

Entrez Gene: 25216 Rat

Omim: 186355 Human

SwissProt: P18827 Human

SwissProt: P18828 Mouse

SwissProt: P26260 Rat

Unigene: 224607 Human

Unigene: 665958 Human

Unigene: 2580 Mouse

Unigene: 11176 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Syndecan1(CD138)屬于Syndecans基因家族,該家族是一類細胞表面跨膜蛋白多糖 ,是膜表面粘附受體 ,參與細胞-細胞外基質(zhì)之間的粘附。
CD138表達于上皮細胞、胚胎間質(zhì)細胞、血管平滑肌細胞、內(nèi)皮細胞和神經(jīng)細胞基底膜。Syndecan-1與惡性腫瘤的發(fā)生發(fā)展、浸潤及轉(zhuǎn)移有關(guān),著色于胞漿和胞膜.
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