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Rabbit Anti-HIF 2 alpha  antibody (bs-1447R)  
~~~促銷,代碼KT202502A~~~
~~~促銷,代碼KT202502B~~~
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產品編號 bs-1447R
英文名稱 Rabbit Anti-HIF 2 alpha  antibody
中文名稱 缺氧誘導因子2α /EPAS1抗體
別    名 Basic helix loop helix PAS protein MOP2; Basic-helix-loop-helix-PAS protein MOP2; bHLHe73; Class E basic helix-loop-helix protein 73; ECYT4; Endothelial PAS domain containing protein 1; Endothelial pas domain protein 1; Endothelial PAS domain-containing protein 1; EPAS 1; EPAS-1; EPAS1; EPAS1_HUMAN; HIF 1 alpha like factor; HIF-1-alpha-like factor; HIF-2-alpha; HIF2-alpha; HIF2A; HLF; Hypoxia inducible factor 2 alpha; Hypoxia inducible factor 2 alpha subunit; Hypoxia-inducible factor 2-alpha; Member of PAS protein 2; Member of pas superfamily 2; MOP 2; MOP2; PAS domain-containing protein 2; PASD2.  
Specific References  (11)     |     bs-1447R has been referenced in 11 publications.
[IF=5.174] Xiong Y et al. Physiological and genetic convergence supports hypoxia resistance in high-altitude songbirdsPLoS Genet.2020 Dec 28;16(12):e1009270.  WB ;  Bird.  
[IF=4.451] Shiying Huang. et al. Jujube polysaccharides mitigated anemia in rats with chronic kidney disease: Regulation of short chain fatty acids release and erythropoietin production. J Funct Foods. 2021 Nov;86:104673  IHC ;  Rat.  
[IF=3.414] Tang Q et al. Aqueous?extract?from?You-Gui-Yin?ameliorates?cognitive?impairment?of?chronic?renal?failure?micethrough?targeting?hippocampal?CaMKIIα/CREB/BDNF?and?EPO/EPOR pathways. J Ethnopharmacol. 2019 Jul 15;239:111925.  WB ;  Mouse.  
[IF=3.35] Li, Xu, et al. "Oxidative stress induces the decline of brain EPO expression in aging rats." Experimental Gerontology (2016).  WB ;  Rat.  
[IF=2.752] Yanyu He. et al. Altered Hypoxia-Induced and Heat Shock Protein Immunostaining in Secondary Hair Follicles Associated with Changes in Altitude and Temperature in Tibetan Cashmere Goats. Animals-Basel. 2021 Oct;11(10):2798  IF,IHC ;  goat.  
[IF=2.611] Cui, Yan. et al. Effects of PHD and HSP90 on erythropoietin production in yak (Bos grunniens) renal interstitial fibroblast-like cells under hypoxia. J Mol Histol. 2022 Jan;:1-17  IHC ;  Yak.  
[IF=2.466] Jinjiang Yang. et al. Platelet-rich plasma attenuates interleukin-1β-induced apoptosis and inflammation in chondrocytes through targeting hypoxia-inducible factor-2α. Tissue Cell. 2021 Sep;:101646  WB ;  rat.  
[IF=1.832] He Y et al. Association of Age with the Expression of Hypoxia-Inducible Factors HIF-1α, HIF-2α, HIF-3α and VEGF in Lung and Heart of Tibetan Sheep. Animals (Basel). 2019 Sep 11;9(9). pii: E673.  IHC-P ;  Sheep.  
[IF=1.719] Lixin L et al. Effect?of?Hypoxia?on the?Muscle?Fiber?Switching?Signal?Pathways?CnA/NFATc1?and?Myostatin?in?Mouse?Myocytes. Acta Histochem. 2019 Jul;121(5):539-545.  WB ;  Mouse.  
[IF=1.58] Li, Hao, et al. "Prognostic value of CD147 and HIF-2α expression in localized clear cell renal cell carcinoma." Int J Clin Exp Pathol 9.9 (2016): 9394-9400.  IHC-P ;  Human.  
[IF=0.78] Yang K et al. Expression and distribution of HIF-1α, HIF-2α, VEGF, VEGFR-2 and HIMF in the kidneys of Tibetan sheep, Plain sheep and goat. Folia Morphol (Warsz). 2020 Feb 5.  IHC-P ;  Sheep.  
研究領域 腫瘤  免疫學  信號轉導  細胞凋亡  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,Rat (predicted: Human)
產品應用 WB=1:500-2000,Flow-Cyt=1:20-100,ICC/IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 96kDa
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse HIF 2 Alpha: 1-130/874 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

Function:
Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerizes with ARNT. Interacts with CREBPB.

Subcellular Location:
Nucleus (Potential).

Tissue Specificity:
Expressed in most tissues, with highest levels in lung, followed by heart, kidney, brain and liver. Predominantly expressed in endothelial cells. Also found in smooth muscle cells of the uterus, neurons, and brown adipose tissue. High expression in embryonic choroid plexus and kidney glomeruli.

Post-translational modifications:
In normoxia, is probably hydroxylated on Pro-405 and Pro-530 by EGLN1/PHD1, EGLN2/PHD2 and/or EGLN3/PHD3. The hydroxylated prolines promote interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation. Under hypoxia, proline hydroxylation is impaired and ubiquitination is attenuated, resulting in stabilization.
In normoxia, is hydroxylated on Asn-851 by HIF1AN thus probably abrogating interaction with CREBBP and EP300 and preventing transcriptional activation.
Phosphorylated on multiple sites in the CTAD.
The iron and 2-oxoglutarate dependent 3-hydroxylation of asparagine is (S) stereospecific within HIF CTAD domains.

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.
Contains 1 PAC (PAS-associated C-terminal) domain.
Contains 2 PAS (PER-ARNT-SIM) domains.

SWISS:
P97481

Gene ID:
13819

Database links:

Entrez Gene: 282711 Cow

Entrez Gene: 2034 Human

Entrez Gene: 13819 Mouse

Entrez Gene: 100037272 Pig

Entrez Gene: 29452 Rat

Omim: 603349 Human

SwissProt: Q99814 Human

SwissProt: P97481 Mouse

SwissProt: Q9JHS1 Rat

Unigene: 468410 Human

Unigene: 1415 Mouse

Unigene: 55138 Rat



HIF-2α也是機體對缺氧適應性調節(jié)中的重要調控蛋白.有學者認為:HIF-2α對腫瘤的能量代謝和新血管生成有促進作用,微血管的形成可抑制腫瘤細胞的凋亡,從而促進腫瘤的惡性發(fā)展。
產品圖片
25 ug total protein per lane of various lysates (see on figure) probed with HIF 2 alpha polyclonal antibody, unconjugated (bs-1447R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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